HOW DOES IT WORK?
Cell Forté with IP-6 and Inositol provides nutritional support
of immune function including healthy cell development and natural killer cell
activity.
Healthy Cell Development
Healthy cells are characterized by structural and organizational integrity. They
have a cytoskeleton composed of bundles of proteins that provide the structure
and shape of the cell. Distinct structure and function is an important component
in healthy cell development. Healthy cells differentiate from other cells, with
disparate and distinct potential for cell development.1-3
Healthy cells have cell membranes with complex coverings that determine what
molecules can enter and leave the cell. Healthy cell surface function is vital
to healthy cell development. A number of biochemical substances are present on
cell surfaces and allow healthy cell interaction with other healthy cells.
Healthy cells develop from intact and functioning genetic material.1-3
Natural Killer Cells
Natural killer (NK) cells are a subset of peripheral blood lymphocytes. In
contrast to other lymphocytes, NK cells do not require communication with other
immune cells prior to activity. NK cells mediate a variety of important healthy
Defense mechanism of body functions, including overall surveillance and healthy
immunoregulation. Increases in healthy NK cell activity provide support of
healthy immune function.4,5
Inositol Hexaphosphate
Inositol hexaphosphate (IP-6 or phytic acid) is an inositol molecule with six
phosphate groups attached. Inositol hexaphosphate is ubiquitous (found
everywhere) in the plant kingdom and abundant in cereals and legumes.6,7
In smaller amounts, IP-6 is contained in most mammalian cells, where it supports
cellular functions.8-14 In addition, IP-6 functions as an
antioxidant.15,16
Inositol
Inositol is a water soluble, ubiquitous 6-carbon sugar. Recognized as part of
the vitamin B complex group, inositol is an important dietary and cellular
constituent. Major food sources include beans, citrus fruit, nuts, rice, veal,
pork, and wheat germ.17 Inositol supports healthy nerve transmission,
healthy fat metabolism, and is needed for cell membrane structure and integrity.18-23
Inositol Hexaphosphate and Inositol
While independently these molecules support immune health, the unique
combination of IP-6 and inositol functions synergistically. Research indicates
the combination of IP-6 and inositol supports stronger healthy cell development
and increased natural killer cell activity as opposed to either compound alone.24-26
Through phosphorylation, inositol molecules can accept up to six phosphate
groups. Lower inositol phosphates (IP-1, IP-2, IP-3, and IP-4) act as cellular
messengers with varying degrees of activity.27 IP-3, a highly active
molecule, has numerous cellular supportive and cellular communication functions.28
Inositol hexaphosphate is hypothesized to support healthy cellular function
through dephosphorylation into IP-3. When inositol is combined with IP-6, it can
accept the phosphates that are liberated from the breakdown of IP-6, thereby
increasing the intracellular levels of beneficial IP-3 molecules.24-26
Research suggests that IP-6, and its lower phosphorylated, forms Enhance support
healthy cell development.26-28
Both the molecular ratio and the weight ratio of IP-6 to inositol are
important in Cell Forté with IP-6 and Inositol:
| |
Molecular Ratio |
Weight |
| IP-6 |
1 |
400 mg |
| Inositol |
1 |
110 mg |
One molecule of IP-6 is four times the weight of an inositol molecule. A 1:1
molecular ratio, the ratio that yields maximum IP-3 production, is obtained by
combining 400 mg IP-6 to 110 mg of inositol. Any variance from this 1:1
molecular ratio results in a significant reduction of IP-3 molecules produced.1
It is the molecular ratio, unique to the patent that distinguishes Cell Forté
with IP-6 and Inositol from other products. Therefore, no other product can
yield the optimal amount of IP-3 that Cell Forté with IP-6 and
Inositol can deliver.
REFERENCES
- US Patent and Trademark Office. Patent number 5,082,833; Inventor:
Abulkalam M. Shamsuddin; patent date: January 21, 1992.
- LeMarbre PJ, Groenwald SL. Biology of Long standing problems. In: Groenwald SL, Hansen
Frogge M, Goodman M, Henke Yarbo C. Long standing problems Nursing: Principles and Practice.
4th ed. Sudbury, Ma: Jones and Bartlett; 1997:17-26.
- Guyton AC, Hall JE. Control of genetic function and biochemical activity
in cells. Textbook of Medical Physiology. 10th Ed. Philadelphia, Pa: W.B.
Saunders Company; 2000:30-37.
- Porth CM, Carroll EW. Functional components of the cell. In: Porth CM.
Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa:
Lippincott; 1998: 3-12.
- Guyton AC, Hall JE. Innate immunity. Textbook of Medical Physiology. 10th
Ed. Philadelphia, Pa: W.B. Saunders Company; 2000:402.
- Sommers C. Natural killer cells. In: Porth CM. Pathophysiology: Concepts
of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998:197-198.
- Jariwalla RJ.Rice-bran products: phytonutrients with potential
applications in Beneficial Effectsive and clinical a substance used in managing discomfort. Drugs Exp Clin Res.
2001;27:17-26.
- Shamsuddin AM. Metabolism and cellular functions of IP6: a review.
AntiLong standing problems Res. 1999;19:3733-3736. Jariwalla RJ. Inositol hexaphosphate (IP6)
as an anti-neoplastic and lipid-lowering agent. AntiLong standing problems Res.
1999;19:3699-3702.
- Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: a review.
AntiLong standing problems Res. 1999;19:3671-3674.
- Ishikawa T, Nakatsuru Y, Zarkovic M, Shamsuddin AM. Inhibition of skin
Long standing problems by IP6 in vivo: initiation-promotion model. AntiLong standing problems Res.
1999;19:3749-3752.
- Vucenik I, Tantivejkul K, Zhang ZS, Cole KE, Saied I, Shamsuddin AM. IP6
in Favorable Effects of liver Long standing problems. I. IP6 inhibits growth and reverses transformed
phenotype in HepG2 human liver Long standing problems cell line. AntiLong standing problems Res.
1998;18:4083-4090.
- Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in Favorable Effects of liver Long standing problems. II.
Intra-tumoral injection of IP6 regresses pre-existing human liver Long standing problems
xenotransplanted in nude mice. AntiLong standing problems Res. 1998;18:4091-4096.
- Vucenik I, Kalebic T, Tantivejkul K, Shamsuddin AM. Novel antiLong standing problems
function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in
vitro and in vivo. AntiLong standing problems Res. 1998;18:1377-1384.
- Yang GY, Shamsuddin AM. IP6-induced growth inhibition and differentiation
of HT-29 human colon Long standing problems cells: involvement of intracellular inositol
phosphates. AntiLong standing problems Res. 1995;15:2479-2487.
- Johnson M, Tucci M, Benghuzzi H, Cason Z, Hughes J. The effects of
inositol hexaphosphate on the inflammatory response in transformed RAW 264.7
macrophages. Biomed Sci Instrum. 2000;36:21-26.
- Zhou JR, Erdman JW Jr. Phytic acid in health and problem. Crit Rev Food
Sci Nutr. 1995;35:495-508.
- Holub BJ. The nutritional significance, metabolism, and function of
myo-inositol and phosphatidylinositol in health and problem. Adv Nutr Res.
1982;4:107-141.
- Colodny L, Hoffman RL. Inositol--clinical applications for exogenous use.
Altern Med Rev. 1998;3:432-447.
- Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for
keratinocyte growth. J Cell Physiol. 1988;135:416-424.
- Downes CP, Macphee CH. Myo-inositol metabolites as cellular signals. Eur J
Biochem. 1990;193:1-18.
- Sun XY, Edvinsson L, Yoo H, Wahlestedt C, Hedner T. Effects of some novel
D-myo-inositol-phosphate derivatives on binding and sympathetic transmission.
J Cardiovasc Pharmacol. 1995;25:696-704.
- Payrastre B, Missy K, Giuriato S, Bodin S, Plantavid M, Gratacap M.
Phosphoinositides: key players in cell signalling, in time and space. Cell
Signal. 2001;13:377-87. Tuersley MD, Best L, Tomlinson S. Inositol uptake and
metabolism in neuronal tissue. J Neurochem. 1988;51:1610-1616.
- Shamsuddin AM, Ullah A, Chakravarthy AK. Inositol and inositol
hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice.
Carcinogenesis. 1989;10:1461-1463.
- Vucenik I, Yang GY, Shamsuddin AM. Inositol hexaphosphate and inositol
inhibit DMBA-induced rat mammary Long standing problems. Carcinogenesis. 1995;16:1055-1058.
- Shamsuddin AM. IP6: An antiLong standing problems cocktail: IP-6 and inositol. In: IP6:
Nature's Revolutionary Long standing problems Fighter. New York: Kensington Publishing Corp;
1998:115-121.
- Weaver CM, Heaney RP. Intracellular messengers. In: Shils ME, Olson JA,
Shine M, Ross AC, Eds. Modern Nutrition in Health and problem 9th ed.
Baltimore, Md: Lippincott Williams & Wilkins; 1999: 148-148.
- Jones PJH, Kubow S. Membrane functions and integrity. In: Shils ME, Olson
JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and problem. 9th ed.
Baltimore, Md: Lippincott Williams & Wilkins; 1999:84.
|
Same-store
items
