The Benefits of Coenzymated Sublingual Vitamins In order for vitamins to be utilizied by the body, they must first be converted into their active coenzyme forms. This Coenzymated sublingual B-6 goes directly into your bloodstream in its active form, ready to go to work immediately. This avoids the loss that may occur not only during digestion, but during the liver's conversion process as well. Pyridoxal-5'-Phosphate (PLP or P-5'-P) is the main metabollically active coenzyme form of vitamin B-6. It is primarily in the liver that P-5'-P is synthesized from pyridoxine, with the Enhance of enzymes that require B-2, zinc and magnesium for their activity. P-5'-P is associated with numerous enzymes, many of which are involved in the conversion of amino acids into the neurotransmitters dopamine, norepinephrine and serotonin. P-5'-P is also required for the synthesis of the hemoglobin molecule.