Echinacea is one of North America's most celebrated and relied-upon botanicals for mobilizing natural immune defenses. Modern studies have shown that it supports immune resistance by enhancing macrophage activity in vitro. Goldenseal is equally legendary as a winter health botanical. This combination is one of the most popular combinations of herbs in America. Despite its popularity, Planetary Formulas refused to come out with this product for many years so as not to contribute to the decimation of wild goldenseal populations. The echinacea and goldenseal roots used in this preparation are obtained from cultivated sources only, to insure that future generations have access to these precious botanicals.