This purified extract of crude guggul gum from the small mukul tree was first discovered in India, and has been used ever since. With its two active ingredients, Z-Guggulsterone and E-Guggulsterone active at an average of 2.5%, the refined resin supports healthy cardiovascular circulation. Some studies have also reported that these active guggulsterones may be able to assist the body in normalizing cholesterol levels while encouraging healthy Defense mechanism of body response.