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Jarrow Formulas¨ pharmaceutical grade, stabilized SAM-e JOINT offers a full 200 mg elemental SAM-e and 525 mg of Glucosamine hydrochloride in every enteric-coated tablet. SAM-e JOINT is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAM-e and Glucosamine are known to benefit joint function and recuperation.

SAM-e
Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active formÊis the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow FORMULAS' SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.
Glucosamine
Glucosamine is an aminosaccharide synthesized by transamidase enzymes from glucose and an amine group from glutamine. HCl (hydrochloric acid) stabilizes the Glucosamine in this product. Glucosamine is a component of joint and intestinal tissue and is involved in the production of synovial fluid which lubricates the joints.

SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:

Joint Strength
SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.
Brain Metabolism
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, epinephrine and phosphatidylcholine (a component of lecithin).
Liver
SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.
Longevity
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.